EGFRvIII

EGFR is a transmembrane protein that promotes cell proliferation when activated.¹ Deletion of exons 2-7 in the extracellular domain of EGFR results in a mutant form of the receptor, EGFRvIII, that cannot bind its ligands but is constitutively active with continuous downstream signaling and impaired degradation.²

It is estimated that up to 60% of EGFR-amplified glioblastomas have the EGFRvIII mutation, which is associated with poor prognosis and shorter survival. EGFRvIII is exclusively expressed in tumor cells, making it an attractive therapeutic target.²

Learn more about modalities targeting EGFRvIII:
BiTE^® technology.

Search our clinical trials.

EGFR: epidermal growth factor receptor.