DLL3

Delta-like protein 3 (DLL3) is an inhibitory protein of Notch signaling that is involved in embryonic patterning and has been implicated in neuroendocrine cell development.¹ DLL3 is typically located in the Golgi apparatus and cytoplasmic vesicles, where it inhibits Notch signaling by preventing the processing and cell surface expression of Notch.²

In high-grade neuroendocrine tumors—including small cell lung cancer (SCLC)—DLL3 is upregulated and expressed on the cell surface, with absent or rare expression on nonmalignant cells.^1,3 This makes DLL3 an attractive potential target for investigating a BiTE^® molecule aimed at neuroendocrine tumors, such as SCLC.

Learn more about modalities targeting DLL3:
BiTE^® immunotherapy.

Watch this video for an overview of the role of DLL3 in SCLC and the mechanism of action of a DLL3-targeted BiTE^® molecule.

Download a factsheet that highlights the biology of DLL3 and its potential as a therapeutic target in SCLC and other neuroendocrine tumors.

Download an educational deck that overviews the unmet need in SCLC, T-cell engager technology, and the potential of DLL3 as a target for BiTE^® Immunotherapy.

 

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Visit our resources section for additional information on potential oncogenic targets.