STEAP1

Six-transmembrane epithelial antigen of prostate 1 (STEAP1) is a membrane protein primarily expressed in the prostate tissue, where it is localized in the plasma membrane of epithelial cells located at cell-to-cell junctions.¹ STEAP1 expression is low or absent in normal tissues, and its expression is increased in several types of human cancers.^1,2

STEAP1 is overexpressed in > 80% of prostate cancers, including bone and lymph node metastases, representing an attractive target for treating metastatic castration-resistant prostate cancer (mCRPC).^1-3

 

Learn more about modalities targeting STEAP1:
XmAb^® antibody.

Download an educational resource for additional information on STEAP1, a therapeutic target in mCRPC.

 

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