KIF18A
Kinase-like protein 18A (KIF18A) is a mitotic kinesin motor protein that regulates chromosome positioning during cell division and is overexpressed in a subset of human cancers.1-3
Preclinical studies of KIF18A gene inactivation suggest its function can be dispensable for normal somatic cell division,4,5 but cancer cells with chromosomal instability depend on KIF18A for cell division and survival,6,7 making KIF18A a potential therapeutic target.
Learn more about modalities targeting KIF18A:
small molecules.
Search our clinical trials.
Visit our resources section for additional information on potential oncogenic targets.
1. Rath O, Kozielski F. Nat Rev Cancer. 2012;12(8):527-539. 2. Mayr MI, Hümmer S, Bormann J, et al. Curr Biol. 2007;17(6):488-498. 3. Stumpff J, von Daasow G, Wagenbach M, Asbury C, Wordeman L. Dev Cell. 2008;14(2):252-262. 4. Czechanski A, Kim H, Byers C, et al. Dev Biol. 2015;402(2):253-262. 5. Fonseca CL, Malaby HLH, Sepaniac LA, et al. J Cell Biol. 2019;218(4):1148-1163. 6. Marquis C, Fonseca CL, Queen KA, et al. Nat Comm. 2021;12:1213. 7. Quinton RJ, DiDomizio A, Vittoria MA, et al. Nature. 2021;590(7846):492-497.