IL-21R

Interleukin-21 receptor (IL-21R) is a type I cytokine receptor that is broadly expressed by hematopoietic cells, including T and B lymphocytes, natural killer cells, and myeloid cells. The IL-21R ligand, IL-21, is produced by activated CD4+ T cells and natural killer cells.^1-3

IL-21, a potent mitogen and survival factor for activated T cells and natural killer cells, has emerged as a potential immunomodulator that acts on tumor-infiltrating lymphocytes to enhance the antitumor immune response.^1,3

Learn more about modalities targeting IL-21R:
bifunctional fusion proteins.

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Visit our resources section for additional information on potential oncogenic targets.

CD, cluster of differentiation.